光调控生物材料界面实现稳定黏附与按需脱附的柔性神经生物电子器件

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Published: 26 October 2026

npj Flexible Electronics (2026) Cite this article

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Abstract

Dynamic bioelectronic interfaces are required to simultaneously ensure stable tissue integration for chronic recording and controllable debonding for device reconfiguration or retrieval. This challenge is particularly acute for implantable neural interfaces, where weak adhesion compromises signal fidelity, while permanent adhesion may cause secondary tissue damage during removal. Here, we developed a photo-programmable neural biointerface incorporating a self-healing bPDMS@Fe matrix based on a carboxyl-functionalized polydimethylsiloxane network dynamically crosslinked by Fe³⁺-carboxylate coordination. The resulting electrode exhibits robust adhesion to diverse substrates and biological tissues, as well as on-demand removal through UV-induced adhesion weakening. Moreover, it supports stable epidermal electrocardiogram recording under various conditions. Furthermore, the biointerface is translated into a 9-channel cortical electrode array that enables stable local field potential recording and spatiotemporal mapping of seizure-associated neural activity in freely moving mice. This work establishes a dynamic adhesive strategy as a new materials design paradigm for neural bioelectronic interfaces toward next-generation chronic electrophysiological monitoring devices.

Acknowledgements

The authors acknowledge the Fudan Nano-fabrication Lab for support with nanofabrication.

Funding

The authors would like to acknowledge the support from the National Natural Science Foundation of China (32300935, 32130044 and T2241002), Shanghai Rising Star Program (23YF1407200), National Key R&D Program of China (2024YFF0507601), Changping Laboratory (2025B-07-21), Brain Science and Brain-like Intelligence Technology-National Science and Technology Major Project (2021ZD0202500), and Program of Shanghai Academic/Technology Research Leader (21XD1400100). The funders had no role in the study design, data collection and analysis, preparation of the manuscript, or decision to publish.

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Authors and Affiliations

Department of Pain Management, Huadong Hospital, State Key Laboratory of Brain Function and Disorders, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
Zili Li, Binbin Hu, Quansheng He, Zhongzhong Wang, Liting Sun, Haoyi Yang, Xiaoxue Zhang, Yousheng Shu & Miao Tang
College of Future Information Technology, Fudan University, Shanghai, China
Zili Li
Department of Neurosurgery, Shanghai Deji Hospital-The 9th Clinical College, Qingdao University, Shanghai, China
Hui Guo

Authors

Zili Li
Binbin Hu
Quansheng He
Zhongzhong Wang
Liting Sun
Haoyi Yang
Xiaoxue Zhang
Hui Guo
Yousheng Shu
Miao Tang

Corresponding author

Correspondence to Miao Tang.

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The authors declare no competing interests.

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Li, Z., Hu, B., He, Q. et al. Light-regulated biomaterial interfaces enable flexible neural bioelectronics with stable adhesion and on-demand detachment for chronic electrophysiology. npj Flex Electron (2026). https://doi.org/10.1038/s41528-026-00659-w

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Received: 12 July 2026
Accepted: 07 October 2026
Published: 26 October 2026
DOI: https://doi.org/10.1038/s41528-026-00659-w