Merck 与科伦博泰 sac-TMT 在晚期子宫内膜癌 III 期研究中将死亡风险降低三分之一
STAT+: Merck ADC drug cut risk of death by one-third in advanced endometrial cancer
Merck 与科伦博泰（Kelun-Biotech）联合开发的靶向化疗药物 sac-TMT（sacituzumab tirumotecan）在随机 III 期研究中将晚期子宫内膜癌患者的死亡风险降低三分之一，结果于周一在 ESMO 2026 公布。
sac-TMT 在晚期子宫内膜癌 III 期研究中将死亡风险降低三分之一，读者可据此了解 Merck 在 Keytruda 专利到期前的管线布局。
Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast The Readout Loud and author of the newsletter Adam’s Biotech Scorecard. You can reach Adam on Signal at stataf.54.
MADRID — A type of targeted chemotherapy developed by Merck and China’s Kelun-Biotech cut by one-third the risk of death in patients with advanced endometrial cancer, a common gynecological cancer, according to randomized Phase 3 study results presented Monday.
The drug, called sacituzumab tirumotecan, or sac-TMT, has already shown survival-extending benefits for patients across multiple cancer types in studies conducted by Kelun in China, where it’s approved.
Merck is conducting 18 global Phase 3 studies of sac-TMT, including 10 studies in women’s cancers, to support approvals in the U.S., Europe, and elsewhere outside China. The drug plays a crucial role in Merck’s efforts to replace revenue that will be lost when Keytruda, its blockbuster immunotherapy, loses patent protection in 2028.
STAT+ Exclusive Story
Already have an account? Log in
This article is exclusive to STAT+ subscribers
Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+.
Already have an account? Log in
To read the rest of this story subscribe to STAT+.
来源：STAT News · statnews.com